Hydracarbazine 

Hydracarbazine is a pyridazine. Hydracarbazine can effectively lower blood pressure, it can be used for the research of high blood pressure^[1][2].

Hydracarbazine (1-4 mg/kg; i.v. once) induced in the dog, cat and rabbit hypotension by peripheral vasodilation, showed no inhibitory action on vasomotor centers and decreased the hypertensive effects of adrenaline, noradrenaline, 5-hydroxytryptamine, pituitrin, and splanchnic nerve stimulation^[1].
Hydracarbazine (15-18 mg/kg; p.o. once daily) prevents the increased blood pressure and heart rate, reduces the renal histol and reduces the hypertensive syndrome with a combination of pempidine in high arterial pressure rats^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

153.14

C₅H₇N₅O

3614-47-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Schmitt H, et al. Pharmacological study of a new hypotensor with a long duration of action: 1-hydrazino-4-carboxamidopyridazine (1325). Journal de Physiologie. 1992 52:525-36.

  [2]. Ghaye-Roquet J, et al. [Prevention of experimental hypertension in the rat by prolonged administration of a combination of antihypertensive agents]. Arch Int Pharmacodyn Ther. 1967 Mar;166(1):65-78.  [Content Brief]