2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Hydroxy desmethyl Bosentan

Hydroxy desmethyl Bosentan  (Synonyms: Ro 64-1056)

目录号: HY-135390
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摩尔计算器

Hydroxy desmethyl Bosentan (Ro 64-105) 是一种 Bosentan 代谢物。在肝脏中由细胞色素 P450 酶 CYP2C9 和 CYP3A4 催化产生的。Bosentan 是一种有效的 endothelin-1 (ET) 拮抗剂，在人的 SMC 细胞中，作用于 ETA 和 ETB 受体，Ki 值分别为 4.7 nM 和 95 nM。Bosentan 可用于研究肺动脉高压。

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Hydroxy desmethyl Bosentan Chemical Structure

Hydroxy desmethyl Bosentan Chemical Structure

CAS No. : 253688-62-9

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规格 价格 是否有货
500 μg ￥2529
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Hydroxy desmethyl Bosentan 相关抗体

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  • 生物活性

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生物活性

Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2].

分子量

553.59

Formula

C26H27N5O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hydroxy desmethyl Bosentan 相关分类

  • 摩尔计算器

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Keywords:

Hydroxy desmethyl Bosentan253688-62-9Ro 64-1056Drug MetaboliteInhibitorinhibitorinhibit

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