2. Immunology/Inflammation
  3. NO Synthase
  4. iNOs-IN-3

iNOs-IN-3 (Compound 2d) 是一种具有口服活性的一氧化氮合成酶 (iNOS) 抑制剂 (IC50=3.342 µM)。iNOs-IN-3 具有抗炎活性，可用于 LPS 诱导的急性肺损伤 (ALI) 研究。

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iNOs-IN-3 Chemical Structure

iNOs-IN-3 Chemical Structure

CAS No. : 2241674-94-0

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iNOs-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research[1].

IC50 & Target

IC50: 3.342 µM (iNOS)[1]
体外研究
(In Vitro)

iNOs-IN-3 (25 μM; 24 h) inhibits LPS-induced RAW 264.7 cells[1].
iNOs-IN-3 (12.5 μM; 24 h) can decrease the expression of iNOS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

iNOs-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW 264.7 microphages
Concentration: 25 μM
Incubation Time: 24 hours
Result: Showed higher inhibitory activity (IC50=14.72 µM) in LPS-induced RAW 264.7 cells.

Cell Viability Assay[1]

Cell Line: RAW 264.7 microphages
Concentration: 12.5 μM
Incubation Time: 24 hours
Result: Inhibited the LPS-induced mRNA expression of iNOS obviously.

Cell Viability Assay[1]

Cell Line: RAW 264.7 microphages
Concentration: 12.5 μM
Incubation Time: 24 hours
Result: Inhibited the expression of TNF-α, IL-6, and IL-1β at 12.5 µM.
体内研究
(In Vivo)

iNOs-IN-3 (oral administration; 12.5 mg/kg; once) treatment shows anti-inflammatory activity against xylene-induced ear edema in mice[1].
iNOs-IN-3 (oral administration; 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg; once) protects against LPS-induced acute lung injury[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xylene-induced mice[1]
Dosage: 12.5 mg/kg
Administration: Oral administration; 12.5 mg/kg; once
Result: Showed better activity than the positive control.
Animal Model: LPS-induced acute lung injury (ALI) mice[1]
Dosage: 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg
Administration: Oral administration; 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg; once
Result: Attenuated the pathological lesions dose-dependently, such as decreased inflammatory infiltration and pulmonary congestion. Inhibited LPS-induced lung edema dose-dependently.
分子量

488.55

Formula

C27H24N2O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

iNOs-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iNOs-IN-32241674-94-0NO SynthaseNitric oxide synthasesNOSanti-inflammatory activityacute lung injuryALIRAW 264.7Inhibitorinhibitorinhibit

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