2. Apoptosis
  3. c-Myc Apoptosis
  4. IZTZ-1

IZTZ-1 是一种咪唑-苯并噻唑缀合物，是一种 c-MYC G4 配体。IZTZ-1 通过稳定 c-MYC G4 下调 c-MYC 的表达。IZTZ-1 诱导细胞周期阻滞，凋亡 (apoptosis)，从而抑制 B16 细胞的增殖。IZTZ-1 具有抗肿瘤活性，可用于黑色素瘤的研究。

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IZTZ-1 Chemical Structure

IZTZ-1 Chemical Structure

CAS No. : 2636771-45-2

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IZTZ-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].

体内研究
(In Vivo)

IZTZ-1 (0-20 mg/kg, IP, once every two days, for 10 days) effectively inhibits tumor growth in a melanoma mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

549.73

Formula

C32H35N7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IZTZ-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IZTZ-12636771-45-2IZTZ1IZTZ 1c-MycApoptosisMycB16 cellsc-MYCG-quadruplexmelanomaImidazoleBenzothiazoleInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147973
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