2. Cytoskeleton
  3. Myosin
  4. JB062

JB062 是一种非肌肉肌球蛋白 (nonmuscle myosin) 抑制剂，对骨骼肌肌球蛋白、心肌肌球蛋白和平滑肌肌球蛋白 II 的 IC50 值分别为分别为 1.6、5.4 和 >100 μM。JB062 对人类癌细胞具有细胞毒性，但对正常细胞没有细胞毒性。JB062 可用于肌肉痉挛、慢性肌肉骨骼疼痛和肥厚型心肌病的研究。

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JB062 Chemical Structure

JB062 Chemical Structure

CAS No. : 2417988-00-0

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规格 价格 是否有货 数量
1 mg ￥2210
1 周
5 mg   询价  
10 mg   询价  

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Customer Review

JB062 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].

IC50 & Target

IC50: 1.6 μM (Skeletal muscle myosin), 5.4 μM (Cardiac muscle myosin), and >100 μM (Smooth muscle myosin II)[1]
体外研究
(In Vitro)

JB062 (compound 6b; 40 μM; 24 h) 抑制 COS-7 细胞的胞质分裂[1]。
JB062 (COS-7 细胞) 对人类癌细胞具有细胞毒性，但对正常细胞没有细胞毒性，CC10 值为 36 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JB062 相关抗体:
分子量

323.34

Formula

C19H17NO4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JB062 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JB0622417988-00-0JB 062JB-062Myosinmuscle spasticitychronic musculoskeletal painhypertrophic cardiomyopathycytokinesisCOS-7 cellInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-152206
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