2. Anti-infection
  3. Enterovirus
  4. Jun6504

Jun6504 是一种肠道病毒 (enterovirus) 2C 蛋白抑制剂。Jun6504 对 EV-D68 (EC50 = 250 nM)、EV-A71 (EC50 = 502.4 nM) 和 CVB3 (EC50 = 1049 nM) 的多种毒株均表现出强效广谱抗病毒活性。Jun6504 在 EV-D68 感染的新生小鼠模型中可改善瘫痪评分并促进体重增长。Jun6504能降低脊髓和感染股四头肌中的病毒滴度。Jun6504 可用于 EV-D68 抗病毒研究。

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Jun6504

Jun6504 Chemical Structure

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Jun6504 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Jun6504 is an enterovirus 2C inhibitor. Jun6504 shows potent and broad-spectrum antiviral activity against multiple strains of EV-D68 (EC50 = 250 nM), EV-A71 (EC50 = 502.4 nM), and CVB3 (EC50 = 1049 nM). Jun6504 improves paralysis score and weight gain in a neonatal mouse model of EV-D68 infection. Jun6504 reduces viral titers in the spinal cord and the infected quadriceps muscle. Jun6504 can be used for EV-D68 antiviral research[1].

体外研究
(In Vitro)

Jun6504 (1-10000 nM) 在 RD 细胞中对 EV-D68、EV-A71 和 CVB3 的抗病毒活性 EC50 值分别为250 nM、502.4 nM 和 1049 nM[1]。
Jun6504 (1-10000 nM, 60 h) 在 RD 细胞中对 5 株 EVD68 毒株 (US/MO114-18947、USMO114-18949、USIL/14-18952、US/L14-18956、USKY114-18953) 具有抗病毒活性，EC50 值范围为 0.25 至 0.47 µM[1]。
Jun6504 (0.01-10 μM, 3 天) 在 CPE 实验中显示对 CVA16、CVA6、1 型脊髓灰质炎病毒和 CVB3 的剂量依赖性抑制 (EC50 为 0.24-0.57 µM)，并在 RD 细胞中抑制 EV-A71 和 EV-D68 的噬斑形成 (EC50 分别为 0.22 µM 和 0.13 µM)[1]。
Jun6504 (1-1000 μM) 引起EV-A71、EV-D68和CVB3的2C蛋白Tm剂量依赖性升高[1]。
Jun6504 通过阻断病毒复制周期中间阶段抑制EV-D68扩增 (在感染前或感染后 3 hpi 添加有效，5 hpi 和7 hpi 添加时抑制效果减弱)[1]。
Jun6504 (12.8-100 μM) 在 RD 细胞中对 P3、P6 和 P9 病毒的 EC50 分别为0.80 μM、3.38 μM和 15.45 μM，并且对 P7 和 P10 病毒完全丧失抗病毒活性 (EC50 >30 µM)[1]。
Jun6504 (0.001-10 μM) 对 r2C-I112V/D183V/D323G 的抑制活性最弱 (EC50 = 3.77 µM)，对 EV-D68 的 2C 突变蛋白 (F190L、D183V/F190L、D183V/F190L/D323G) 无抗病毒活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Jun6504 相关抗体:
体内研究
(In Vivo)

Jun6504 (50 mg/kg，腹腔注射，每日一次，持续 13-14 天) 在 EV-D68 感染的新生小鼠模型中可改善瘫痪评分并促进体重增长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neonatal mice were infected with EV-D68 by intramuscular injection into the left quadriceps muscle[1]
Dosage: 50 mg/kg
Administration: i.p. immediately following intramuscular infection once daily for 14 days or i.p. at 24 h post-infection and continued daily for 13 days
Result: Showed significantly lower paralysis scores and significantly increased body weight gain.
Showed significantly lower viral titers in the spinal cords.
Showed no EV-D68-infected (NeuN+) neurons.
Showed VP2-positive neurons in the lumbar enlargement.
分子量

327.42

Formula

C18H25N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Jun6504 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Jun6504Jun 6504Jun-6504EnterovirusRhinovirusHRVHRVsHEVHEVsEV-D68EV-A71CVB3enterovirusInhibitorinhibitorinhibit

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