2. Immunology/Inflammation
  3. NO Synthase
  4. L-NIL dihydrochloride

L-NIL dihydrochloride 是诱导型一氧化氮合成酶 (iNOS) 的抑制剂，其对 miNOS 的 IC50 值为3.3 μM。

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L-NIL dihydrochloride Chemical Structure

L-NIL dihydrochloride Chemical Structure

CAS No. : 159190-45-1

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L-NIL dihydrochloride 的其他形式现货产品:

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Other Forms of L-NIL dihydrochloride:

L-NIL dihydrochloride 相关抗体

Top Publications Citing Use of Products

    L-NIL dihydrochloride purchased from MCE. Usage Cited in: J Adv Res. 5 March 2022.

    Inhibiting iNOS with L-NIL (10 μM) blunted the adverse effect of iNOS expression in cardiomyocytes.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].

    IC50 & Target

    IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[3].
    体外研究
    (In Vitro)

    L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    L-NIL dihydrochloride 相关抗体:
    体内研究
    (In Vivo)

    L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Balb/c (20-25 g)[1].
    Dosage: 10 and 30 mg/kg.
    Administration: Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
    Result: Led to a negligible increase in plasma NGAL compared to sham mice.
    Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript.
    Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
    Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
    分子量

    260.16

    Formula

    C8H19Cl2N3O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    L-NIL dihydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-NIL159190-45-1NO SynthaseNitric oxide synthasesNOSNLRP3InflammasomeAcuteKidneyInjuryPolymicrobialSepsisAKIIL-1βInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
    HY-12118
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