1. 寡核苷酸
  2. siRNAs
  3. Lumasiran

Lumasiran (Synonyms: ALN-G01)

目录号: HY-132588
产品使用指南

Lumasiran (ALN-G01) 是一种 siRNA 化合物,通过靶向乙醇酸氧化酶 (glycolate oxidase) 减少肝脏草酸的产生。Lumasiran 通过沉默编码乙醇酸氧化酶的基因,消耗乙醇酸氧化酶,从而抑制草酸的合成,草酸是一种与原发性高草酸尿1型 (PH1) 表现直接相关的有毒代谢物。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Lumasiran Chemical Structure

Lumasiran Chemical Structure

CAS No. : 1834610-13-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货
1 mg ¥9800
询问价格 & 货期
5 mg ¥24500
询问价格 & 货期
10 mg ¥39000
询问价格 & 货期

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 哈根达斯、星巴克、KFC、百果园 等专属礼券

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1)[1][2].

体外研究
(In Vitro)

Lumasiran reduced urinary oxalate excretion, the cause of progressive kidney failure in PH1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Lumasiran is a subcutaneously administered, liver-directed RNA interference (RNAi) therapeutic agent[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

16340.00

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

H2O : 100 mg/mL (6.12 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.0612 mL 0.3060 mL 0.6120 mL
5 mM 0.0122 mL 0.0612 mL 0.1224 mL
10 mM --- --- ---
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Lumasiran
目录号:
HY-132588
需求量: