1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. MAP4343

MAP4343 

目录号: HY-107116
产品使用指南

MAP4343 是 Pregnenolone 的 3-甲基醚衍生物。MAP4343 在体外与微管相关蛋白 2 (MAP2) 结合,刺激微管蛋白的聚合,增强神经突的延伸并保护神经元免受神经毒性剂的侵害。

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MAP4343 Chemical Structure

MAP4343 Chemical Structure

CAS No. : 511-26-2

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Description

MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2].

In Vitro

MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro[1].
MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells[1].
MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells[1]

In Vivo

MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats[2].
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats[2].
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats[2].

Animal Model: Adult Sprague-Dawley male rats with spinal cord injury[2]
Dosage: 12 mg/kg
Administration: Daily s.c. for 28 days
Result: Increased the number of animals able to walk with weight-supported plantar steps.
Showed forelimb-hindlimb coordination at the end of the study.
Molecular Weight

330.50

Formula

C₂₂H₃₄O₂

CAS No.

511-26-2

SMILES

C[C@@]1([C@H]2C(C)=O)[C@](CC2)([H])[C@@](CC=C(C3)[C@@]4(CC[C@@H]3OC)C)([H])[C@]4([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
C1   V1   C2   V2

Keywords:

MAP4343MAP 4343MAP-4343Microtubule/TubulinPregnenolonemicrotubule-associatedprotein2MAP2polymerizationtubulinneuritesInhibitorinhibitorinhibit

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产品名称:
MAP4343
目录号:
HY-107116
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