2. Academic Validation
  3. 4-Aminopyridine ameliorates experimental autoimmune neuritis in Lewis rats

4-Aminopyridine ameliorates experimental autoimmune neuritis in Lewis rats

  • J Neuroimmunol. 2017 Apr 15:305:72-74. doi: 10.1016/j.jneuroim.2017.01.023.
Kota Moriguchi 1,  Katsuichi Miyamoto 2,  Susumu Kusunoki 3
Affiliations

Affiliations

  • 1 Division of Neurology, Department of Internal Medicine 3, National Defense Medical College, Tokorozawa, Japan; Department of Internal Medicine, Japan Self Defense Forces Hanshin Hospital, Kawanishi, Japan.
  • 2 Department of Neurology, Kinki University School of Medicine, Osaka-Sayama, Japan. Electronic address: miyamoto@med.kindai.ac.jp.
  • 3 Department of Neurology, Kinki University School of Medicine, Osaka-Sayama, Japan.
PMID: 28284349 DOI: 10.1016/j.jneuroim.2017.01.023
Abstract

We investigated the effect of 4-aminopyridine (4-AP) on experimental autoimmune neuritis (EAN) using a 4-AP-treated group in which 4-AP was administered in the diet, and a control group (n=10 per group). Electrophysiological and pathological assessment was performed in the sciatic nerve. The EAN clinical scores were significantly lower in the 4-AP-treated group than in the control group (p<0.05). The motor conductance velocity two weeks post-immunization was significantly higher in the 4-AP-treated group (p<0.05). Finally, 4-AP did not lead to pathological changes. Thus, 4-AP might be a potential therapeutic agent in demyelinating neuropathy.

Keywords

4-Aminopyridine; Experimental autoimmune neuritis; Guillain-Barré syndrome.

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