2. Academic Validation
  3. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression

6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression

  • Biochem Biophys Res Commun. 2024 Sep 10:724:150217. doi: 10.1016/j.bbrc.2024.150217.
Muhammad Shahid 1,  Fazal Subhan 2,  Nisar Ahmad 3,  Zia Ud Din 4,  Ihsan Ullah 5,  Shafiq Ur Rahman 6,  Rahim Ullah 7,  Umar Farooq 7,  Javaid Alam 8,  Noor Ul Ain Nawaz 9,  Sudhair Abbas 7,  Robert D E Sewell 2
Affiliations

Affiliations

  • 1 Department of Pharmacy, CECOS University of Information Technology and Emerging Sciences, Peshawar, 25000, Khyber Pakhtunkhwa, Pakistan. Electronic address: shahidsalim_2002@hotmail.com.
  • 2 Department of Pharmacy, CECOS University of Information Technology and Emerging Sciences, Peshawar, 25000, Khyber Pakhtunkhwa, Pakistan.
  • 3 School of Pharmacy, Institute of Health Sciences, Mardan, Khyber Pakhtunkhwa, Pakistan.
  • 4 Department of Anatomy, Khyber Medical College, Peshawar, Khyber Pakhtunkhwa, Pakistan.
  • 5 Department of Pharmacy, University of Swabi, Swabi, Khyber Pakhtunkhwa, Pakistan.
  • 6 Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Dir, Khyber Pakhtunkhwa, Pakistan.
  • 7 Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
  • 8 Drug and Herbal Research Center, Faculty of Pharmacy, University Kebangsang Malaysia, Kuala Lumpur, 50300, Malaysia.
  • 9 Department of Pharmacy, City University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
PMID: 38865809 DOI: 10.1016/j.bbrc.2024.150217
Abstract

Neuropathy is a disturbance of function or a pathological change in nerves causing poor health and quality of life. A proportion of chronic pain patients in the community suffer persistent neuropathic pain symptoms because current drug therapies may be suboptimal so there is a need for new therapeutic modalities. This study investigated the neuroprotective flavonoid, 6-methoxyflavone (6MF), as a potential therapeutic agent and gabapentin as the standard comparator, against neuropathic models. Thus, neuropathic-like states were induced in Sprague-Dawley rats using sciatic nerve chronic constriction injury (CCI) mononeuropathy and systemic administration of streptozotocin (STZ) to induce polyneuropathy. Subsequent behaviors reflecting allodynia, hyperalgesia, and vulvodynia were assessed and any possible motoric side-effects were evaluated including locomotor activity, as well as rotarod discoordination and gait disruption. 6MF (25-75 mg/kg) antagonized neuropathic-like nociceptive behaviors including static- (pressure) and dynamic- (light brushing) hindpaw allodynia plus heat/cold and pressure hyperalgesia in the CCI and STZ models. 6MF also reduced static and dynamic components of vulvodynia in the STZ induced polyneuropathy model. Additionally, 6MF reversed CCI and STZ suppression of locomotor activity and rotarod discoordination, suggesting a beneficial activity on motor side effects, in contrast to gabapentin. Hence, 6MF possesses anti-neuropathic-like activity not only against different nociceptive modalities but also impairment of motoric side effects.

Keywords

Allodynia; Analgesia; Flavonoids; Hyperalgesia; Neuropathy; Neuroprotective.

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