2. Academic Validation
  3. Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism

Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism

  • Sci Bull (Beijing). 2025 Jul 30;70(14):2297-2311. doi: 10.1016/j.scib.2025.05.003.
Yanping Jia 1,  Yingdong Liu 1,  Yanhe Li 1,  Xiaohong Guan 1,  Junting Xu 2,  Zihui Yan 1,  Kuisheng Liu 1,  Yalin Zhang 1,  Dandan Bai 1,  Jiani Xiang 1,  Yan Zhang 1,  Shangyu Hou 1,  Xiaochen Kou 1,  Yanhong Zhao 1,  Jiqing Yin 1,  Hong Wang 1,  Kunming Li 3,  Shaorong Gao 4,  Wenqiang Liu 5
Affiliations

Affiliations

  • 1 Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • 2 Reproductive Center of Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
  • 3 Reproductive Center of Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: likunming@51mch.com.
  • 4 Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address: gaoshaorong@tongji.edu.cn.
  • 5 Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Reproductive Center of Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: liuwenqiang@tongji.edu.cn.
PMID: 40441968 DOI: 10.1016/j.scib.2025.05.003
Abstract

Assisted reproductive technology (ART) is associated with increased implantation failure and subsequent metabolic abnormalities in offspring, but the underlying mechanisms remain largely elusive. Here, we reveal that persistent Wnt signaling during the peri-implantation stage may be a key obstacle to the implantation of in vitro fertilization (IVF) embryos in a mouse model. Wnt activation affects the deposition of H3K27ac and H3K27me3 on pluripotency genes and bivalent genes, respectively, leading to the abnormal naïve-primed transition and suppressing expression of Otx2 in the epiblast. Furthermore, treatment with the Wnt Inhibitor IWP2 promotes the redistribution of histone modifications and gene expression of epiblast. Importantly, Wnt inhibiting significantly improves implantation and intrauterine development of IVF embryos and subsequently ameliorates offspring metabolic abnormalities. Moreover, Wnt inhibiting markedly improves human peri-implantation embryo development and facilitates the transition from a naïve pluripotency state. Our study reveals a novel mechanism underlying the prevention of IVF embryo implantation failure and metabolic disorders in offspring.

Keywords

Embryo implantation; H3K27ac; H3K27me3; Metabolic abnormalities; Naïve pluripotency; Otx2; Wnt signal pathway.

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