2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Metallo-β-lactamase-IN-7

Metallo-β-lactamase-IN-7 是一种有效的 VIM 型金属 β-内酰胺酶 (metallo-β-lactamase) 抑制剂，对VIM-2、VIM-1和VIM-5 的 IC50 为 0.019 μM、13.64 μM 和 0.38 μM。Metallo-β-lactamase-IN-7 能增强 Meropenem 对革兰氏阴性菌的抗菌活性。

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Metallo-β-lactamase-IN-7 Chemical Structure

Metallo-β-lactamase-IN-7 Chemical Structure

CAS No. : 2752453-58-8

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Metallo-β-lactamase-IN-7 相关抗体

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Metallo-β-lactamase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains[1].

IC50 & Target

IC50: 0.019 μM (VIM-2), 13.64 μM (VIM-1), 0.38 μM (VIM-5)[1]
体外研究
(In Vitro)

Metallo-β-lactamase-IN-7 (compound 59) (10 μM; 18 - 20 hours) can potentiate Meropenem activity against VIM-2 mediated antibacterial resistance with FIC index values of 0.02[1].
Metallo-β-lactamase-IN-7 (100 μM) potentiates the antibacterial activity of Meropenem against PA W35 with FIC index values of 0.125[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metallo-β-lactamase-IN-7 相关抗体:
分子量

274.30

Formula

C12H10N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Metallo-β-lactamase-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metallo-β-lactamase-IN-72752453-58-8Beta-lactamaseBacterialβ-lactamaseMetallo-β-lactamaseVIMMeropenemSynergistic antibacterial activityGram-negative bacterialEscherichia coliPseudomonas aeruginosaInhibitorinhibitorinhibit

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