2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Metallo-β-lactamase-IN-9

Metallo-β-lactamase-IN-9 (Compound 23) 是泛金属-β-内酰胺酶 (MBL) 抑制剂，对 NDM-1、VIM-1 和 IMP-1 的 IC50 分别为 35、269 和 369 nM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Metallo-β-lactamase-IN-9 Chemical Structure

Metallo-β-lactamase-IN-9 Chemical Structure

CAS No. : 1802363-75-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Metallo-β-lactamase-IN-9 相关抗体

Top Publications Citing Use of Products

查看 Beta-lactamase 亚型特异性产品:

查看所有亚型
Metallo-β-lactamase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively[1].

IC50 & Target

IC50: 35 nM (NDM-1), 269 nM (VIM-1), 369 nM (IMP-1)[1]
体内研究
(In Vivo)

Metallo-β-lactamase-IN-9 (Compound 23) (10 and 50 mg/kg; s.c.; three times a day for 1 day) 在小鼠 Klebsiella pneumoniae MB9249 感染模型中与 Imipenem (HY-B1369A) 联用减少脾脏和肾脏的细菌负担[1]。
Mouse Pharmacokinetic Properties of Metallo-β-lactamase-IN-9 (Compound 23)d[1]

dosea(iv, mpk) AUC (μM·h) MRT (h) Vdss (L/kg) Cl (mL/min/kg)
5a 27.08 5.2 2.97 9.33

dose (sc, mg/kg) AUC (μM·h) Cmax (μM) Tmax (h)
10b 27.42 13.4 0.83
50c 111.28 69.1 0.5

aFormulation, 1.0 mg/mL 23 in 20% DMSO/60% PEG400/20% water (solution) with dose volume of 5 mL/kg.
bFormulation, 1.0 mg/mL of 23 in 30% captisol (solution) with dose volume 10 mL/kg.
cFormulation, 5.0 mg/mL of 23 in 30% captisol (solution) with dose volume of 10 mL/kg.
dAUC, area under the curve; Cl, clearance; iv, intravenous, MRT, mean residence time; Vdss, volume of distribution at steady state.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cytoxan-treated DBA-2 mice, Klebsiella pneumoniae MB9249 infection model[1]
Dosage: 10 and 50 mg/kg, in combination with 5mg/kg Imipenem (HY-B1369A)
Administration: Subcutaneous injection, three times a day for 1 day
Result: Demonstrated reduction of bacterial burden in both the spleen and kidney to a greater extent while combining with Imipenem (HY-B1369A) relative to Imipenem (HY-B1369A) alone.
Animal Model: C57BL/6 mice[1]
Dosage: Intravenous and subcutaneous injection
Administration: 5, 10 and 50 mg/kg (Pharmacokinetic Analysis)
Result: Showed good pharmacokinetic properties.
分子量

332.34

Formula

C13H12N6O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Metallo-β-lactamase-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metallo-β-lactamase-IN-91802363-75-2Beta-lactamaseBacterialβ-lactamaseNDM-1VIM-1IMP-1Klebsiella pneumoniaeMB9249ImipenemInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Metallo-β-lactamase-IN-9
目录号：
HY-152105
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z