1. Apoptosis
  2. Apoptosis
  3. (-)-Hinesol

(-)-Hinesol  (Synonyms: Hinesol)

目录号: HY-N1930
产品使用指南

(-)-Hinesol (Hinesol) 是一种有效的抗癌剂。(-)-Hinesol 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期 (-)-Hinesol 下调 MEK/ERK 通路和 NF-κB 通路并介导 cyclin D1、Bax 和 Bcl-2 的表达。(-)-Hinesol 具有研究非小细胞肺癌的潜力。

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(-)-Hinesol Chemical Structure

(-)-Hinesol Chemical Structure

CAS No. : 23811-08-7

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1].

体外研究
(In Vitro)

(-)-Hinesol (0-25 µg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner[1].
(-)-Hinesol (0, 2, 8 µg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1[1].
(-)-Hinesol (0, 2, 8 µg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change for the total protein levels of IκBα and p65 in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A549, NCI-H1299 cells
Concentration: 0-25 µg/ml
Incubation Time: 24, 48 h
Result: Inhibited the proliferation of the A549 and NCI-H1299 cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0, 2, 8 µg/ml
Incubation Time: 24 h
Result: Induced apoptosis with the apoptotic cells was increased to 21.2 ± 0.96% and 36 ± 1.04% after treatment with hinesol at 2 and 8 μg/mL, respectively.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0, 2, 8 µg/ml
Incubation Time: 24 h
Result: Increased the protein expression of Bax and decreased the expression of Bcl-2.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0, 2, 8 µg/ml
Incubation Time: 24 h
Result: Showed concentration-dependent increase in the percentage of cell in the G0/G1 phase, and a decrease of the percentage in G2/M phase.
分子量

222.37

Formula

C15H26O

CAS 号
中文名称

茅苍术醇

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

(-)-Hinesol 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(-)-Hinesol
目录号:
HY-N1930
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