2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Mitiglinide

Mitiglinide  (Synonyms: KAD-1229 free acid anhydrous; S21403 free acid anhydrous)

目录号: HY-B0682
产品使用指南

摩尔计算器

Mitiglinide (KAD-1229) 属于促胰岛素化合物，是一种 ATP 敏感的 K+ 通道 (KATP channel) 拮抗剂。Mitiglinide 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性。Mitiglinide 可用于 2 型糖尿病的研究。

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Mitiglinide Chemical Structure

Mitiglinide Chemical Structure

CAS No. : 145375-43-5

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Mitiglinide 的其他形式现货产品:

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Mitiglinide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mitiglinide (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide can be used for the research of type 2 diabetes[1][2].

IC50 & Target

KATP channel[1]
体外研究
(In Vitro)

Mitiglinide inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 of 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mitiglinide 相关抗体:
体内研究
(In Vivo)

Mitiglinide (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant Wistar rats (12 weeks)[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Dose-dependently suppressed AUCglucose levels.
Clinical Trial
分子量

315.41

Formula

C19H25NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mitiglinide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitiglinide145375-43-5KAD-1229 free acidS21403 free acidPotassium ChannelKcsAhypoglycaemicinsulinotropictype2diabetesanti-diabeticInhibitorinhibitorinhibit

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