2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Mitobronitol

Mitobronitol  (Synonyms: Myelobromol; DBM)

目录号: HY-13641
产品使用指南

摩尔计算器

Mitobronitol (Myelobromol; DBM) 是甘露醇的溴化类似物，也是一种抗癌剂，被归类为烷基化剂。Mitobronitol 有抑制骨髓的潜力，与显著降低加速慢性粒细胞白血病异体骨髓移植的几种并发症的风险相关。

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Mitobronitol Chemical Structure

Mitobronitol Chemical Structure

CAS No. : 488-41-5

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Mitobronitol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia[1][2].

体内研究
(In Vivo)

Mitobronitol (850 mg/kg; i.p.; single dose) improves spleen cells to mitogens and enhances thymus regeneration in mice model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (8-10 weeks old)[2]
Dosage: 850 mg/kg; 1500 mg/kg (suspended in 5% Tween 80 in saline, 0.5 mL)
Administration: Intraperitoneal injection; single dose
Result: Showed effect on the in vitro proliferative response of spleen cells to mitogens at 850 mg/kg.
Enhanced thymus regeneration and was earlier than control, with the starting resititution time-course of 2 weeks and subtotal resititution time course of 3 weeks under 1500 mg/kg dose.
Clinical Trial
分子量

307.97

Formula

C6H12Br2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mitobronitol 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Mitobronitol488-41-5Myelobromol DBMDNA Alkylator/Crosslinkeranticancerbrominated sugar alcohol derivativealkylationantimetabolitemannitolmyelosuppressionInhibitorinhibitorinhibit

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