2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. MNAC13

MNAC13 是一种小鼠 IgG1 嵌合抗体，靶向 TrkA (人源)。MNAC13 通过特异性结合 TrkA 受体来抑制 NGF 依赖性的信号通路。MNAC13 具有良好的镇痛效果和持久性。MNAC13 可用于炎症和慢性疼痛的研究。

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MNAC13

MNAC13 Chemical Structure

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Customer Review

MNAC13 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

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TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MNAC13 is a kind of mouse IgG1 chimeric antibody, targeting to human TrkA. MNAC13 inhibits the NGF dependent signaling pathway by specifically binding to TrkA receptors. MNAC13 has good analgesic effect and long-lasting efficacy. MNAC13 can be used for researches on inflammatory and chronic pain[1][2].

反应种属

Human
IC50 & Target[1][2]

TrkA

 

体外研究
(In Vitro)

MNAC13 (200-300 μg/mL，1 小时) 在过表达 TrkA 的 3T3 细胞中特异性结合 TrkA，并且抑制 NGF 依赖性信号传导[1]。
MNAC13 (4 μg/mL，4 天) 有效阻断 PC12 细胞中 NGF 诱导的细胞存活和轴突生长[2]。
MNAC13 (2 或 20 ng/mL) 在 TrkA BALB/C 3T3 细胞中特异性结合 TrkA 免疫粘附素，但不结合 TrkB[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MNAC13 相关抗体:

Western Blot Analysis[1]

Cell Line: 3T3 cells overexpressing TrkA
Concentration: 200-300 μg/mL
Incubation Time: 1 h
Result: Significantly inhibited the phosphorylation of TrkA and the phosphorylation level of downstream signaling molecule PLCγ1.
体内研究
(In Vivo)

MNAC13 (0.9-60 μg；腹腔注射或皮下注射；单次剂量；福尔马林试验前 18 小时) 显著减轻了注射了 5 % 福尔马林溶液的 CD1 雄性小鼠的炎性疼痛[1]。
MNAC13 (30-70 μg；腹腔注射；每日一次；从第 3 天到第 10 天) 在慢性收缩损伤 (CCI) CD1 雄性小鼠中显著减轻了神经性疼痛，并表现出持久性[1]。
MNAC13 (1 μg；腹腔注射；单次剂量；试验前 15 分钟) 与阿片类药物联合在 5 % 福尔马林溶液注射的 CD1 雄性小鼠中具有显著的协同镇痛作用[1]。
MNAC13 在注射了 MNAC13 杂交瘤细胞的 Wistar 大鼠中，阻断 TrkA 对 BFCNs 的影响比阻断 NGF 更显著且持久[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 % formalin solution injected CD1 male mice (30-40 g)[1]
Dosage: 0.9, 1.875, 3.75, 7.5, 15, 30 and 60 μg
Administration: Subcutaneous injection (s.c.) of 0.9, 1.875, 3.75, 7.5, 15, 30 and 60 μg; Intraperitoneal injection (i.p.) of 15μg
Result: Significantly reduced late stage licking behavior and was also effective for early pain at 15 μg.
Animal Model: CCI CD1 male mice (30-40 g)[1]
Dosage: 30, 50 and 70 μg
Administration: Intraperitoneal injection (i.p.); once daily from day 3 to day 10
Result: Significantly reduced mechanical allodynia and has long-lasting effects.
Animal Model: 5 % formalin solution injected CD1 male mice (30-40 g)[1]
Dosage: 1 μg; combinated with morphine (1 mg/kg) or fentanyl (5 μg/kg)
Administration: Intraperitoneal injection (i.p.); 15 min before the test
Result: Generated significant synergistic analgesic effect.
Acted on the central nervous system and naloxone failed to reverse the synergistic effect.
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MNAC13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNAC13MNAC 13MNAC-13Trk ReceptorTropomyosin related kinase receptorTrkANGFanalgesiainflammationpainInhibitorinhibitorinhibit

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