2. GPCR/G Protein
  3. CRFR
  4. NBI 35965 hydrochloride

NBI 35965 hydrochloride 是一种选择性、具有口服活性、可穿过血脑屏障的促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，Ki 值为 4 nM，pKi 值为 8.5，并且不抑制 CRF2。NBI 35965 hydrochloride 可减少体内 CRF 或应激诱导的促肾上腺皮质激素 (ACTH) 的产生，pIC50 值分别为 7.1 和 6.9。NBI 35965 hydrochloride 具有抗焦虑作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NBI 35965 hydrochloride Chemical Structure

NBI 35965 hydrochloride Chemical Structure

CAS No. : 1782228-59-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of NBI 35965 hydrochloride:

NBI 35965 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects[1][2].

IC50 & Target[1][2]

CRFR1

4 nM (Ki)

CRFR1

8.5 (pKi)

体外研究
(In Vitro)

NBI 35965 hydrochloride 对 CRF1 表现出高亲和力，但对 CRF2 没有结合亲和力。在 CRF1 转染细胞中，NBI 35965 hydrochloride 还可抑制 Sauvineine 诱导的 cAMP 刺激[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NBI 35965 hydrochloride 相关抗体:
体内研究
(In Vivo)

NBI 35965 hydrochloride（20 mg/kg；口服灌胃；一次）可减少小鼠应激诱导的 ACTH 产生[1]。
在大鼠中，NBI 35965 hydrochloride（化合物 12a；10mg/kg）的分布容积为 17.8 L/kg，血浆清除率为 17 mL/min/kg，半衰期为 12 小时。估计口服生物利用度为 34%，1 小时平均最大血浆浓度为 560 ng/mL。NBI 35965 hydrochloride 也能穿透血脑屏障，导致平均最大脑浓度为 700 ng/g[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice (24-26 g) bearing restraint stress[1]
Dosage: 20 mg/kg (10 mL/kg 5% mannitol-d (w/v) in water)
Administration: Oral gavage; 60 min prior to the initiation of the stressor
Result: Reduced stress induced ACTH production in vivo.
分子量

437.79

Formula

C21H23Cl3N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NBI 35965 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBI 359651782228-59-4NBI35965NBI-35965CRFRCorticotropin-releasing Factor ReceptorCRHRCRF1 AntagonistACTHorally activebrain-penetrantanxiolytic effectsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
NBI 35965 hydrochloride
目录号：
HY-110056
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z