2. Epigenetics Metabolic Enzyme/Protease
  3. Small Interfering RNA (siRNA) Lactate Dehydrogenase
  4. Nedosiran

Nedosiran  (Synonyms: 奈多西兰; DCR-PHXC)

目录号: HY-132606
产品使用指南 技术支持

Nedosiran (DCR-PHXC) 是一种靶向乳酸脱氢酶 (LDH) 的 RNA 干扰剂 (RNAi)。Nedosiran 可用于研究并发终末期肾病 (ESRD) 的原发性高草酸尿症 (PH)。Nedosiran 是一种 GalNAc-dsRNA 偶联物。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Nedosiran sodium。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

RNA,(Am-sp-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)U-Gm-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)C-Um-Gm-Am-Gm-Cm-Am-GmCm-Cm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]G-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-GmCm), complex with RNA ([1-de-β-D-ribofuranosyl-1-[(2R,3R,4S,5S)-tetrahydro-4-hydroxy-5-[(hydroxymethoxyphosphinyl)methoxy]-3-methoxy-2-furanyl]]U-(4'→5')- sp-(2'-deoxy-2'-fluoro)C-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G- (2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)A-Am-(2'-deo

Nedosiran Chemical Structure

CAS No. : 2266591-83-5

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Nedosiran 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate[1][2][3].

体外研究
(In Vitro)

Nedosiran 是一种合成的双链 RNA 寡核苷酸（即小干扰 RNA [siRNA]），旨在靶向编码 LDHA 的 mRNA[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nedosiran 相关抗体:
体内研究
(In Vivo)

Nedosiran 是一种用于研究原发性高草酸尿症的 RNAi 疗法，可选择性降低肝脏乳酸脱氢酶的表达[3]。
Nedosiran 特别抑制肝脏乳酸脱氢酶 (LDHA) 的表达[3]。
Nedosiran 是一种与 GalNAc 结合的双链 siRNA 分子，可利用肝脏中独特的去唾液酸糖蛋白受体 (ASGPR) 递送系统。Nedosiran 通过每月皮下注射给药。Nedosiran 可降低动物模型中的血浆草酸[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

20985.12

Formula

C662H865F19N231O413P57S6
CAS 号
中文名称

奈多西兰
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nedosiran 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nedosiran2266591-83-5DCR-PHXC奈多西兰Small Interfering RNA (siRNA)Lactate DehydrogenaseLDHlactatedehydrogenaseRNAinterferenceInhibitorinhibitorinhibit

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