2. Anti-infection
  3. Influenza Virus
  4. Neuraminidase-IN-18

Neuraminidase-IN-18 (compound N5) 是一种新型多杂环神经氨酸酶 (NA) 抑制剂。Neuraminidase-IN-18 显示出抑制 H5N1 NA 的效力，对野生型 H5N1 NA 和 H5N1-H274Y 突变 NA 的 IC50 分别为 0.14 μM 和 0.27 μM。Neuraminidase-IN-18 通过在细胞水平上与 NA 结合来抑制流感病毒复制。

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Neuraminidase-IN-18 Chemical Structure

Neuraminidase-IN-18 Chemical Structure

CAS No. : 2935407-32-0

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Neuraminidase-IN-18 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC50 of 0.14 μM and 0.27 μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level[1].

体外研究
(In Vitro)

Neuraminidase-IN-18 (compound N5) 通过 CCK-8 方法显示对 H5N1 的体外抗病毒活性，EC50 值为 3.70 μM[1]。
Neuraminidase-IN-18 中的芳香稠环和 1,3,4-恶二唑环很好地嵌入到活性位点中。Neuraminidase-IN-18 可以与活性位点的三个带正电的关键精氨酸残基 (Arg118、Arg292 和 Arg371) 形成强氢键相互作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuraminidase-IN-18 相关抗体:
分子量

423.46

Formula

C22H18FN3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuraminidase-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuraminidase-IN-182935407-32-0Influenza VirusPolyheterocyclicneuraminidaseH5N1H5N1-H274YArg118Arg292Arg371Inhibitorinhibitorinhibit

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