2. Anti-infection
  3. Influenza Virus
  4. Neuraminidase-IN-20

Neuraminidase-IN-20 (Compound 5i) 是 neuraminidase (NA) (H5N1-H274Y) 的抑制剂 (IC50= 0.44 μM)。Neuraminidase-IN-20 与 NA 的 430 腔位结合，干扰 NA 的酶活性。

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Neuraminidase-IN-20 Chemical Structure

Neuraminidase-IN-20 Chemical Structure

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Neuraminidase-IN-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuraminidase-IN-20 (Compound 5i) is a potent inhibitor of mutant neuraminidase (NA) (H5N1-H274Y) (IC50= 0.44 μM).Neuraminidase-IN-20 binds to the 430 cavity site of NA and disrupts the enzymatic activity of NA[1].

体外研究
(In Vitro)

Neuraminidase-IN-20 (45-66 μM; 72 h) 在 A549 细胞中显示出一定的细胞毒性[1]。
Neuraminidase-IN-20 与 NA 中的若干关键残基形成了多个氢键 (比如 Arg118 和 Arg371)，显著提高了对 NA 的抑制效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuraminidase-IN-20 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549 cells
Concentration: 45-66 μM
Incubation Time: 72h
Result: Had cytotoxic at higher concentrations (CC50 = 55.29 μM).
分子量

395.45

Formula

C21H18FN3O2S
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuraminidase-IN-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuraminidase-IN-20Influenza VirusAntiviral Research430-Cavity TargetingA549 cellInhibitorinhibitorinhibit

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