2. Autophagy
  3. Autophagy
  4. Neuroprotective agent 14

Neuroprotective agent 14 是一种可穿透血脑屏障的具有神经保护作用的 1H-苯并咪唑 [d] 类化合物。Neuroprotective agent 14 能够激活自噬 (autophagy)，并清除诱导多能干细胞 (iPSC) 来源的神经祖细胞中 SCMAS 的积累。Neuroprotective agent 14 可用于神经系统疾病的研究，例如神经元蜡样脂褐质沉积症 (NCLs)。

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Neuroprotective agent 14

Neuroprotective agent 14 Chemical Structure

CAS No. : 3086460-57-0

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Neuroprotective agent 14 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuroprotective agent 14 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 14 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 14 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs)[1].

体外研究
(In Vitro)

Neuroprotective agent 14 (Compound 38b) (10 μM, 24 h) 可提高患有 CLN3 的多能干细胞 (iPSC) 衍生神经祖细胞 (NPCs) 的活力，最大保护效应为 73.68%[1]。
Neuroprotective agent 14 (10 μM, 24 h) 可清除患有 CLN3 的 iPSC-NPC 细胞中线粒体 ATP 合酶 c 亚基 (SCMAS) 的异常积累[1]。
Neuroprotective agent 14 (10 μM, 24 h) 可激活患有 CLN3 的 iPSC-NPC 细胞中的自噬通路[1]。
Neuroprotective agent 14 (1-10 μM) 不会激活 Kv7.2/7.3 电压门控钾通道[1]。
Neuroprotective agent 14 显示出穿过血脑屏障的潜力，在小鼠脑匀浆中的结合率为 96.25%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroprotective agent 14 相关抗体:

Cell Autophagy Assay[1]

Cell Line: IPSC-NPC cells with CLN3
Concentration: 10 μM
Incubation Time: 24 h
Result: Increased the immunofluorescence of autophagic cells.
体内研究
(In Vivo)

Neuroprotective agent 14 (Compound 38b) (静脉注射 1 mg/kg，口服 10 mg/kg) 在 Balb/c 小鼠中表现出较高的脑穿透力，脑/血浆浓度比分别为 3.2 和 4.5[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.28

Formula

C16H13F3N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuroprotective agent 14 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Neuroprotective agent 143086460-57-0Neuroprotective agent14Neuroprotective agent-14AutophagyNeuroprotective agentIPSCSCMASneuronal ceroid lipofuscinosesInhibitorinhibitorinhibit

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