2. NF-κB
  3. NF-κB
  4. NF-κB degrader 1

NF-κB degrader 1 (Compound MD-1) 是 NF-κB1 p105 亚基降解剂。NF-κB degrader 1 具有抗炎活性 (抑制 TNF-α 的 IC50 为 2.02 μM，抑制 NO 的 IC50 为 5.40 μM)。NF-κB degrader 1 通过 Cullin-RING 连接酶 (CRL) SCFBTCP 诱导 p105 降解，抑制 NF-κB 转录活性。NF-κB degrader 1 有望用于炎症相关疾病的研究。

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NF-κB degrader 1 Chemical Structure

NF-κB degrader 1 Chemical Structure

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NF-κB degrader 1 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases[1].

IC50 & Target

p50

 

分子量

328.36

Formula

C19H20O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NF-κB degrader 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB degrader 1NF-κBNuclear factor-κBNuclear factor-kappaBNF-κB1TNF-αNOinflammation-related diseasesInhibitorinhibitorinhibit

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产品名称：
NF-κB degrader 1
目录号：
HY-174138
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