2. NF-κB
  3. NF-κB
  4. NF-κB-IN-15

NF-κB-IN-15 (compound 14r) 是一种有效的 NF-κB 抑制剂。NF-κB-IN-15 降低 LPS (HY-D1056) 诱导的细胞中 NO 水平并抑制 IL-6、TNF-α 和 IL-1β 的释放。NF-κB-IN-15 抑制 LPS 诱导的 p65 磷酸化和 IκBα 降解。NF-κB-IN-15 显示抗炎活性具有用于急性肺损伤 (ALI) 研究的潜力。

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NF-κB-IN-15 Chemical Structure

NF-κB-IN-15 Chemical Structure

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NF-κB-IN-15 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI)[1].

体外研究
(In Vitro)

NF-κB-IN-15 (compound 14r) (1.25, 2.5, 5, 10, 20 µM; 1+24 h) 在LPS 诱导的 RAW 264.7 细胞中以剂量依赖性方式降低 NO 水平并抑制 IL-6、TNF-α、IL-1β[1]。
NF-κB-IN-15（10、20 µM；1+4 h） 抑制 LPS 诱导的 p65 磷酸化和 IκBα 的降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-15 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW 264.7 cells[1]
Concentration: 10, 20 µM
Incubation Time: 1 h (LPS (1 μg/mL) for 4 h)
Result: Decreased the expression of p-p65and inhibited degradation of IκBα. LPS-induced levels of IL-6, TNF-α, and IL-1β.
体内研究
(In Vivo)

NF-κB-IN-15 (compound 14r) (20 mg/kg; i.p.) 在急性肺损伤 (ALI) 小鼠中显示出抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-20 g, Male C57BL/6 mice[1]
Dosage: 20 mg/kg+LPS (15 mg/kg, i. p.)
Administration: I.p.
Result: Reduced the LPS-induced levels of IL-6, TNF-α, and IL-1β in the bronchoalveolar lavage fluid (BALF) and acute lung injury.
分子量

794.97

Formula

C46H58N4O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NF-κB-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-15NF-κBNuclear factor-κBNuclear factor-kappaBRAW 264.7 cellsLPSp-p65IκBαIL-6TNF-αIL-1βanti-inflammatoryInhibitorinhibitorinhibit

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目录号：
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