1. NF-κB
  2. Keap1-Nrf2
  3. Nrf2 activator-7

Nrf2 activator-7 (Compound 12b) 是一种有效的 Nrf2 激活剂,可显著激活 Nrf2 信号通路。

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Nrf2 activator-7 Chemical Structure

Nrf2 activator-7 Chemical Structure

CAS No. : 2456295-39-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.

体外研究
(In Vitro)

Nrf2 activator-7 与 Keap1 的结合活性通过 fluorescence polarization (FP) 测定的 IC50 值为 85 nM,通过 time-resolved fluorescence energy transfer (TR-FRET) 测定的 IC50 值为 13.1 nM,并且 Ki 值为 4.9 nM[1]
Nrf2 activator-7(1、10、100 μM;24 h)增加 Nrf2 靶基因(GSTM3、HMOX1 和 NQO1)的转录[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR[1]

Cell Line: NCM460D cells
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Significantly increased transcription of Nrf2 target genes (GSTM3, HMOX1 and NQO1) at 100 μM.
分子量

720.77

Formula

C35H32N2O11S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Nrf2 activator-7 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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