1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. NS-8

NS-8, 一种吡咯衍生物,可激活 Ca2+-敏感的 k+ 通道。NS-8 可通过降低盆腔传入神经活动来抑制排尿反射。NS-8可用于尿频和尿失禁的研究。

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NS-8 Chemical Structure

NS-8 Chemical Structure

CAS No. : 186033-14-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].

体内研究
(In Vivo)

NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 1, 3 and 10 mg/kg
Administration: Intraduodenal administration, intravenous injection
Result: Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure).
Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude.
Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
分子量

215.23

Formula

C12H10FN3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NS-8
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HY-147383
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