1. Apoptosis TGF-beta/Smad
  2. RIP kinase TGF-β Receptor
  3. OD36 hydrochloride

OD36 hydrochloride 是一种 RIPK2 抑制剂,IC50 为 5.3 nM。OD36 hydrochloride 是一种大环抑制剂,可与 ALK2 激酶 ATP 口袋有效结合。OD36 hydrochloride 靶向作用于 ALK2KD 为 37 nM。

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OD36 hydrochloride Chemical Structure

OD36 hydrochloride Chemical Structure

CAS No. : 2387510-88-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with KDs of 37 nM[1][2].

IC50 & Target[1][2]

RIPK2

5.3 nM (IC50)

ACVR1

37 nM (Kd)

ACVR1

47 nM (IC50)

ALK2 R206H

22 nM (IC50)

体外研究
(In Vitro)

OD36 also inhibits ALK2 and ALK2 R206H with IC50s of 47 and 22 nM, respevtively[1].
OD36 shows activity against ALK1 with a KD of 90 nM[2].
OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation[2].
OD36 (0.1-1 μM; 24 h) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells[2].
Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: KS483 cells
Concentration: 0.1, 0.2, and 1 μM
Incubation Time: 24 h
Result: Inhibited BMP-6 induced p-Smad1/5.
体内研究
(In Vivo)

OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis[3]
Dosage: 6.25 mg/kg
Administration: Intraperitoneal injection, 30 min prior to MDP
Result: Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression.
分子量

367.23

Formula

C16H16Cl2N4O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
OD36 hydrochloride
目录号:
HY-19628A
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