1. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  2. Glucocorticoid Receptor
  3. OP-3633

OP-3633 是一种高效的甾体糖皮质激素受体 (GR) 拮抗剂,其 IC50 值为 29 nM,具有 GR 转录活性抑制作用。OP-3633 表现出极弱的孕酮受体受体 (PR) 激动作用和雄激素受体 (AR) 拮抗作用。

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OP-3633 Chemical Structure

OP-3633 Chemical Structure

CAS No. : 2102494-14-2

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  • 生物活性

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生物活性

OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].

IC50 & Target

IC50: 29 nM (GR)[1]

体外研究
(In Vitro)

OP-3633 exhibits low progesterone receptor (PR) agonism with an EC50 higher than 2500 nM[1].
OP-3633 exhibits low androgen receptor (PR) antagonism, with an IC50 of 1135 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

445.64

Formula

C30H39NO2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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OP-3633
目录号:
HY-125839
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