2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Endogenous Metabolite Reactive Oxygen Species
  4. PAA5

PAA5 是一种以甲基化物碳为中心的多核 Au(I) 簇。PAA5 能释放 Au(I)，引起促氧化反应，加速铁死亡。PAA5 以时间依赖性方式增加 pH2AX 的表达。PAA5 具有抗癌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAA5 Chemical Structure

PAA5 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PAA5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity[1].

体外研究
(In Vitro)

PAA5 (0-4 µM; 24 h) induces ferroptosis and increase of the ferroptosis marker gene prostaglandin-endoperoxide synthase 2 (PTGS2). PAA5 decreases cell viability in EJ cells with IC50 values of 1.0 µM and 2.7 µM for EJ and HUVEC cells, respectively[1].
PAA5 (1.5 μM; 4 h; EJ and HUVEC cells) releases active Au(I) metabolites within cells and increases GSH and ROS level[1].
PAA5 (4 µM; 1, 3 and 6 h, EJ cells) causes significant DNA damage as indicated by the increase of histone H2AX phosphorylation (pH2AX)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAA5 相关抗体:

Cell Viability Assay[1]

Cell Line: HUVEC, EJ cells
Concentration: 0, 0.5, 1, 1.5, 2, and 4 µM
Incubation Time: 24 hours
Result: Decreased cell viability of EJ cells 57 and 55%, respectively, compare with HUVEC cells.

Western Blot Analysis[1]

Cell Line: EJ cells
Concentration: 4 µM
Incubation Time: 1, 3, and 6 hours
Result: Increased the expression of pH2AX in a time dependent manner.
体内研究
(In Vivo)

PAA5 (1.5 µM, 100 µL; intravesical delivered into the bladder; 5 times every other day for 8 days) shows anti-tumor activity in mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks, 18 g, female BALB/c nude mice[1]
Dosage: 1.5 µM, 100 µL
Administration: Intravesical delivered into the bladder; 5 times every other day for 8 days
Result: Exhibited a good antitumor effect with the small average tumor volume of 564 ± 180 mm3 after 22 days and no significant body weight loss.
分子量

1348.66

Formula

C14H8Au5B2F8N2-
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAA5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAA5PAA 5PAA-5FerroptosisEndogenous MetaboliteReactive Oxygen SpeciesantiproliferativeEJ cellspH2AXanti-tumororthotopic bladder cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PAA5
目录号：
HY-149036
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z