1. GPCR/G Protein
  2. Vasopressin Receptor
  3. Pecavaptan

Pecavaptan  (Synonyms: BAY 1753011)

目录号: HY-109133
产品使用指南

Pecavaptan 是一种口服有效的非肽类 V1a/V2 受体双拮抗剂,对应的 Ki 分别为 0.5 nM 和 0.6 nM。Pecavaptan 能够促使尿量增加,从而减轻水潴留和水肿等相关症状。

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Pecavaptan Chemical Structure

Pecavaptan Chemical Structure

CAS No. : 1914998-56-3

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查看 Vasopressin Receptor 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema[1].

IC50 & Target[1]

human V1a Receptor

3.6 nM (IC50)

canine V1a Receptor

4.4 nM (IC50)

human V2 Receptor

1.7 nM (IC50)

canine V2 Receptor

1.3 nM (IC50)

体内研究
(In Vivo)

Pecavaptan (0.01, 0.03, 0.1 and 0.3 mg/kg;静脉注射;单剂量) 在犬心动过速诱发的心力衰竭 (HF) 模型中保护免受精氨酸抗利尿激素 (arginine vasopressin, AVP) 介导的心输出量 (CO) 降低)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

543.33

Formula

C22H19Cl2F3N6O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Pecavaptan 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-109133
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