2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. Pentagastrin meglumine

Pentagastrin meglumine  (Synonyms: ICI-50123 meglumine)

目录号: HY-A0261A
产品使用指南

摩尔计算器

Pentagastrin (ICI-50123) meglumine 是一种有效具有选择性的胆囊收缩素 B (CCKB) 受体拮抗剂，对CCKB 和 CCKA 的 IC50 值为 11 nM。Pentagastrin meglumine 可增强胃粘膜对酸的防御机制，并保护胃粘膜免受损伤。

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Pentagastrin meglumine Chemical Structure

Pentagastrin meglumine Chemical Structure

CAS No. : 57448-84-7

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Pentagastrin meglumine 的其他形式现货产品:

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Pentagastrin meglumine 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCKB) receptor antagonists with IC50 values of 11 nM and 1100 nM for CCKB and CCKA, respectively. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury[1].[2].

体外研究
(In Vitro)

Pentagastrin (ICI-50123) meglumine (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold[1].
Pentagastrin (ICI-50123) meglumine (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pentagastrin meglumine 相关抗体:
体内研究
(In Vivo)

Pentagastrin (ICI-50123) meglumine (80 µg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2]
Dosage: 80 µg/kg/h
Administration: Intravenous injection
Result: Protected rat gastric mucosa from acidified aspirin injury. Induced a hyperaemic response to luminal acid challenge, increased mucus gel thickness, and elevated pHi during acid challenge.
Clinical Trial
分子量

963.11

Formula

C44H66N8O14S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pentagastrin meglumine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentagastrin57448-84-7ICI-50123ICI50123ICI 50123Cholecystokinin ReceptorCCK ReceptorCCKB receptorgastric mucosagastric acidInhibitorinhibitorinhibit

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