2. Neuronal Signaling
  3. Amyloid-β
  4. PMN310

PMN310 是一种针对 β 淀粉样蛋白低聚物 (AβO) 的单克隆抗体。PMN310 在体内可预防 AβO 诱导的记忆形成丧失，并减少突触丢失和炎症。PMN310 可用于阿尔兹海默症的研究。

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PMN310

PMN310 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

PMN310 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PMN310 is a monoclonal antibody targeting amyloid-β oligomers (AβO). PMN310 prevents AβO-induced memory loss and reduces synaptic loss and inflammation in vivo. PMN310 is potentially useful in Alzheimer's disease research[1].

同型

Human IgG1 kappa
推荐同型对照抗体
IC50 & Target

Amyloid beta
体内研究
(In Vivo)

PMN310 (30 mg/kg huPMN310，i.p./i.v.，一次) 在老年 WT 小鼠和 APP/PS1 小鼠中显示出中枢神经系统渗透性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aged WT mice (15-17 months old)[1]
Dosage: 30 mg/kg huPMN310
Administration: i.p., once
Result: Induced human IgG production in plasma and perfused brain.
Animal Model: APP/PS1 mice (13-17 months) model[1]
Dosage: 30 mg/kg huPMN310
Administration: i.v., once
Result: Showed CNS penetrance.
基因 ID

351  [NCBI]

Accession
靶点

Amyloid beta
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PMN310 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PMN310PMN 310PMN-310Amyloid-ββ-amyloid peptideAβAbetaAntibodyAlzheimer's diseaseaged WT miceAPP/PS1 miceInhibitorinhibitorinhibit

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目录号：
HY-P991535
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