2. Peptides
  3. PNC-28

PNC-28 是一种 p53 肽，来自 p53 蛋白的 mdm-2 结合结构域(残基 17-26)，其包含膜交叉穿透蛋白序列。PNC-28 可用于胰腺癌研究。

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Custom Peptide Synthesis

PNC-28 Chemical Structure

PNC-28 Chemical Structure

CAS No. : 392661-17-5

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PNC-28 的其他形式现货产品:

Customer Review

Other Forms of PNC-28:

PNC-28 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research[1][2].

体外研究
(In Vitro)

PNC-28 (0-0.5 mg/mL) blocks growth of a lethal human pancreatic cancer cell line[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PNC-28 相关抗体:

Cell Proliferation Assay[2]

Cell Line: MiaPaCa-2 human pancreatic carcinoma cells
Concentration: 0.1, 0.3, and 0.5 mg/mL
Incubation Time: daily
Result: Showed dependent induction of tumor cell death starting at 0.1 mg/ml.
体内研究
(In Vivo)

PNC-28 (2 mg/mouse, SC or IP, for 14 days) blocks the growth of BMRPA1. Tuc3 cells in vivo[1].
PNC-28 (1-20 mg/mouse, SC, for 14 days) inhibits BMRPA1. Tuc3 tumor growth especially if delivered directly to the tumor [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic Nu/Nu mice (7–8 weeks, 22–24 g, injected i.p. with BMRPA1.Tuc3 cells)[1]
Dosage: 2 mg/mouse
Administration: Implanted s.c. or i.p., with 14 days mini-osmotic pumps releasing PNC-28 at a rate of 0.25 μl/hr
Result: No ascites was seen in the PNC-28-treated animals. strongly effective in inhibiting this particular tumor.
Animal Model: Athymic Nu/Nu mice (7–8 weeks, 22–24 g, injected i.p. with BMRPA1.Tuc3 cells)[1]
Dosage: 1 mg/mouse, 10 mg/mouse and 20 mg/mouse
Administration: When the tumors reached sizes from 40 to 260 mg/mouse, mini-osmotic pumps were implanted s.c. that released, over a period of 14 days
Result: Resulted in a significant level of tumor growth inhibition in a dose-related manner.
分子量

3509.13

Formula

C164H255N47O37S
CAS 号
Sequence Shortening

ETFSDLWKLLKKWKMRRNQFWVKVQRG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNC-28392661-17-5PNC28PNC 28Othersanti-tumorpancreatic cancer cellBMRPA1. TUC-3 cellsMiaPaCa-2lactate dehydrogenaseLDHascitesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P3509
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