2. Anti-infection
  3. Bacterial
  4. Pneumolysin-IN-1

Pneumolysin-IN-1 (化合物 PB-3) 是 PLY 的靶向小分子抑制剂 (IC50=3.1 µM)。Pneumolysin-IN-1 PB 是孔道阻塞剂和抗毒力因子。Pneumolysin-IN-1 可用于研究肺炎链球菌引起的感染。

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Pneumolysin-IN-1 Chemical Structure

Pneumolysin-IN-1 Chemical Structure

CAS No. : 330842-49-4

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Pneumolysin-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM). Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae[1].
IC50 & Target

PLY-S61A[1] (3.1 ± 0.4 µM), PLY-N85L[1] (3.1± 0.6 µM), PLY-T55A[1] (1.5± 0.5 µM), PFO[1] (0.33 ± 0.01 µM)
体外研究
(In Vitro)

Pneumolysin-IN-1 (1，3 和 6 µM; 4 和 24 h) 显著抑制 PLY 诱导的细胞损伤，并表现出浓度依赖性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pneumolysin-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 1, 3 and 6 µM
Incubation Time: 4 and 24 h
Result: Prevented more than 95% of cellular damage at 6 µM.
分子量

455.29

Formula

C23H16Cl2N2O4
CAS 号
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pneumolysin-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pneumolysin-IN-1330842-49-4BacterialA549 cellsStreptococcus pneumoniaePneumolysin inhibitorInhibitorinhibitorinhibit

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