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  3. Poly(styrenyl acetal trehalose)

Poly(styrenyl acetal trehalose)  (Synonyms: pSAT)

目录号: HY-150502
产品使用指南

Poly(styrenyl acetal trehalose) (pSAT) 是由海藻糖侧链通过缩醛与聚苯乙烯主链连接而成。Poly(styrenyl acetal trehalose) 稳定多种蛋白质和酶对抗温度波动,不触发先天免疫反应。Poly(styrenyl acetal trehalose) 可用于合成蛋白质-聚合物偶联物,减少肾脏清除活性分子分子。

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Poly(styrenyl acetal trehalose) Chemical Structure

Poly(styrenyl acetal trehalose) Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals. Poly(styrenyl acetal trehalose) stabilizes a variety of proteins and enzymes against fluctuations in temperature, and does not trigger the innate immune response. Poly(styrenyl acetal trehalose) can be used in synthesis of protein-polymer conjugates for reduced renal clearance of the biomolecule[1].

体内研究
(In Vivo)

Poly(styrenyl acetal trehalose) (10 mg/kg; IV, single dosage) does not induce liver or kidney damage, and is safe in terms of acute toxicity in mice[1].
Poly(styrenyl acetal trehalose) (1 mg/kg; IP, twice, at the 0 and 14 day) does not induce the increase of pro-inflammatory cytokines and IgG[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice (6 weeks, n = 6)[1]
Dosage: 10 mg/kg
Administration: IV, single dosage
Result: Did not induce liver or kidney damage, and was safe in terms of acute toxicity.
Animal Model: Female CD-1 mice (6 weeks, n = 6)[1]
Dosage: 1 mg/kg
Administration: IP, twice, at the 0 and 14 day
Result: Did not lead to IgG production.
Led to a slight increase in the IgM level for weeks 1 and 2 but dropped to the negative control level by week 3.
Did not induce the increase of pro-inflammatory cytokines.
Formula

C23H34O11

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Poly(styrenyl acetal trehalose) 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Poly(styrenyl acetal trehalose)
目录号:
HY-150502
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