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  3. Biochemical Assay Reagents
  4. Polycarbophil

Polycarbophil 是一种口服活性亲水性聚合物。Polycarbophil 通过羧基与黏膜表面的氢键作用实现生物黏附，并通过溶胀特性延长化合物滞留时间、调节化合物释放。Polycarbophil 缓解便秘、腹泻。

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Polycarbophil

Polycarbophil Chemical Structure

CAS No. : 9003-97-8

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Polycarbophil 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Polycarbophil is an orally active hydrophilic polymer. Polycarbophil achieves bioadhesion through hydrogen bonding between carboxyl groups and mucosal surfaces, and prolongs compound retention time and regulates compound release through swelling properties. Polycarbophil relieves constipation and diarrhea[1][2][3].

体外研究
(In Vitro)

Polycarbophil (0.5%-1.0% w/v；25-120 min) 使 Pipemidic acid (HY-B1210) 在猪离体膀胱壁中的表观渗透性增加 2.3-4.3 倍，这主要是由于尿路上皮通透性增强所致[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Polycarbophil 相关抗体:
体内研究
(In Vivo)

Polycarbophil (250-1000 mg/kg；口服) 剂量依赖性地增加未给药大鼠的粪便重量和水分含量，且不引起腹泻[3]。
Polycarbophil (500-1000 mg/kg；口服；便秘诱导剂前) 可恢复 Loperamide (HY-156131)/Clonidine (HY-12721) 诱发的便秘大鼠的粪便重量并缓解便秘[3]。
Polycarbophil (500-1000 mg/kg；口服；应激前) 可减少包裹束缚应激 (WRS) 诱发的排便大鼠的应激性粪便排出量[3]。
Polycarbophil (500-1000 mg/kg；口服；腹泻诱导剂前) 在大鼠中可抑制 Castor oil (HY-107799) 诱发的腹泻[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Polycarbophil 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polycarbophil9003-97-8Biochemical Assay Reagentsdiarrhearatsconstipationurinary bladderInhibitorinhibitorinhibit

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