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  3. Biochemical Assay Reagents
  4. Polylactic acid

Polylactic acid (PLA) 是一种生物可降解且生物相容的聚合物，广泛用作药物递送系统的载体以及组织工程和医疗植入物的结构材料。Polylactic acid 通过酯键水解机制作为控释基质，逐步释放包载药物，代谢为无毒乳酸。Polylactic acid 具有可调节的降解速率、机械性能及与其他聚合物复合的能力，可应用于局部或全身药物递送、骨科固定装置及 3D 打印骨再生支架。

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Polylactic acid

Polylactic acid Chemical Structure

CAS No. : 26100-51-6

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Polylactic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Polylactic acid (PLA) is a biodegradable and biocompatible polymer widely used as a carrier for drug delivery systems and a structural material for tissue engineering and medical implants. Polylactic acid acts as a controlled release matrix through the hydrolysis mechanism of ester bonds, gradually releasing the encapsulated drug and metabolizing to non-toxic lactic acid. Polylactic acid has adjustable degradation rate, mechanical properties and the ability to composite with other polymers, and can be used in local or systemic drug delivery, orthopedic fixation devices and 3D printed bone regeneration scaffolds[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
26.61 mM
Compound: Lactic acid
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 25299679]
MRC5 IC50
23.93 mM
Compound: Lactic acid
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 25299679]
体外研究
(In Vitro)

Polylactic acid (PLA) 在 80:20 PLA/PCL 比例 (20 g/L 葡萄糖) 的电纺杂化纳米纤维中显示出比纯聚合物更高效的 5-Fluorouracil (HY-90006) 释放。PLA 微球 (10 mg/mL；35 天) 实现了 Naltrexone (HY-76711) 的持续释放，累积释放率达 67%。3D 打印的 PLA/羟基磷灰石支架 (体内 2 周) 促进了兔颅骨缺损处的成骨细胞增殖和骨形成。PLA 基药物洗脱支架 (10 μg /cm2；30 天) 实现了紫杉醇的可控释放并降低了再狭窄率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Polylactic acid 相关抗体:
Clinical Trial
分子量

60000(Average)

Formula

(C3H6O3)x
CAS 号
性状

固体

颜色

White to off-white

中文名称

聚乳酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 233.33 mg/mL (超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (283 KB)

产品使用指南 (1538 KB)
参考文献

Polylactic acid 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polylactic acid26100-51-6PLA聚乳酸Biochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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