Propionyl coenzyme A lithium 

Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms^[1][2].

Propionyl coenzyme A lithium causes toxic effects due to its accumulation and the impact of its metabolism on cell wall synthesis and maintenance in Mycobacterium tuberculosis^[1].
Propionyl coenzyme A lithium can be converted to β-hydroxypropionic acid via a peroxisomal enzyme-modified β-oxidation pathway in Arabidopsis^[2].
Propionyl coenzyme A lithium causes the formation of propionic acidemia due to its abnormal accumulation, which often occurs in the neonatal developmental stage^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₄H₄₀N₇O₁₇P₃S.xLi

108321-21-7

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Ernesto J Muñoz-Elías, et al. Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol. 2006 Jun;60(5):1109-22.  [Content Brief]

  [2]. Kerry A Lucas, et al. Peroxisomal metabolism of propionic acid and isobutyric acid in plants. J Biol Chem. 2007 Aug 24;282(34):24980-9.  [Content Brief]

  [3]. Oleg A Shchelochkov, et al. Propionic Acidemia. 2012 May 17 [updated 2016 Oct 6]. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.  [Content Brief]