1. GPCR/G Protein
  2. Protease Activated Receptor (PAR)
  3. Protease-Activated Receptor-1 antagonist 3

Protease-Activated Receptor-1 antagonist 3 

目录号: HY-143315
产品使用指南

Protease-Activated Receptor-1 antagonist 3 是一种有效的 蛋白酶激活受体 1 protease-activated receptor-1 拮抗剂,IC50 值为 7 nM。Protease-Activated Receptor-1 antagonist 3 显示与 hERG K+ 通道的结合亲和力,IC50 值为 9 µM[1 ]

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Protease-Activated Receptor-1 antagonist 3 Chemical Structure

Protease-Activated Receptor-1 antagonist 3 Chemical Structure

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查看 Protease Activated Receptor (PAR) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Protease-Activated Receptor-1 antagonist 3 is a potent protease-activated receptor-1 antagonist with an IC50 value of 7 nM. Protease-Activated Receptor-1 antagonist 3 shows binding affinity for hERG K+ channel with an IC50 value of 9 µM[1].

体内研究
(In Vivo)

Protease-Activated Receptor-1 antagonist 3 (compound 23) (3 mg/kg; i.v.) shows 10% bioavailability in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 3 mg/kg
Administration: I.v.
Result: Exhibited relatively high unbound clearance values with CLu of 742 mL/min/kg, and Vd of 1.2 L/kg in rats.
分子量

498.62

Formula

C30H34N4O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Protease-Activated Receptor-1 antagonist 3 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Protease-Activated Receptor-1 antagonist 3
目录号:
HY-143315
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