1. 重组蛋白
  2. Cytokines and Growth Factors
  3. IGF family
  4. Insulin-like Growth Factor I (IGF-1)
  5. IGF-I/IGF-1 蛋白, Human (70a.a)

IGF-I/IGF-1 蛋白, Human (70a.a)

目录号: HY-P7018
COA 产品使用指南

IGF-I/IGF-1 蛋白, Human (70a.a)是一种促进有丝分裂的细胞因子,与 IGF 受体结合,能够调节多种组织的生长,如神经组织、淋巴组织、生殖组织、平滑肌、内皮细胞和骨骼等,同时具有调节神经保护的作用。

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规格 价格 是否有货 数量
10 μg ¥500 In-stock
50 μg ¥1000 In-stock
100 μg ¥1300 In-stock
250 μg   询价  

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描述

IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism.

研究背景

Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice[2].

生物活性

The ED50 is <5 ng/mL as measured by FDC-P1 cells, corresponding to a specific activity of >2.0 × 105 units/mg.

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

P05019 (G49-A118)

基因 ID

3479  [NCBI]

中文名
重组人胰岛素样生长因子-1
同用名
rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I
氨基酸序列

GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

分子量

Approximately 7.7 kDa

性状

Lyophilized powder.

组分

Lyophilized after extensive dialysis against PBS.

内毒素含量

<0.2 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

IGF-I/IGF-1 Protein, Human (70a.a) 相关分类

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IGF-I/IGF-1 Protein, Human (70a.a)
目录号:
HY-P7018
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