2. Immunology/Inflammation
  3. PSMA
  4. PSMA-DIM

PSMA-DIM 是一种二聚体的 PSMA 配体，其对 LNCaP 细胞的 Kd 值为 37.09 nM。PSMA-DIM可以用 [68Ga]Ga 进行放射性标记，形成 [68Ga]Ga-PSMA-DIM。[68Ga]Ga-PSMA-DIM 能够有效地区分不同 PSMA 表达水平的细胞和动物模型。[68Ga]Ga-PSMA-DIM 具有较高 LNCaP 细胞摄取率和的肿瘤摄取峰值。PSMA-DIM 可用于前列腺癌 (PCa) 的研究。

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PSMA-DIM

PSMA-DIM Chemical Structure

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PSMA-DIM 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSMA-DIM is a dimeric PSMA ligand with a Kd of 37.09 nM for LNCaP cells. PSMA-DIM can be radiolabeled with [68Ga]Ga to form [68Ga]Ga-PSMA-DIM. [68Ga]Ga-PSMA-DIM can effectively distinguish between cells and animal models with different expression levels of PSMA. [68Ga]Ga-PSMA-DIM exhibits high LNCaP cells uptake and tumor uptake peak values. PSMA-DIM can be used for the study of prostate cancer (PCa)[1].

体外研究
(In Vitro)

[68Ga]Ga-PSMA-DIM (1.58 nM, 15-120 min) 对 LNCaP 细胞的内吞能力高于 22Rv1 和 PC-3 细胞，其效果取决于 PSMA 的表达水平。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSMA-DIM 相关抗体:
体内研究
(In Vivo)

[68Ga]Ga-PSMA-DIM (5.55 MBq, i.v., 单次剂量) 在 PSMA 阳性的 LNCaP 和 22Rv1 小鼠肿瘤中显示出显著的摄取率，而在 PC-3 肿瘤中则几乎没有摄取[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2649.68

Formula

C119H174IN21O39
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PSMA-DIM 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-DIMPSMAProstate-specific membrane antigenProstate cancerLNCaP cells22Rv1 cellsmice modelInhibitorinhibitorinhibit

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