2. Epigenetics
  3. Epigenetic Reader Domain
  4. (±)-JQ1

(±)-JQ1 是 (+)-JQ-1 (HY-13030) 的外消旋体。

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(±)-JQ1

(±)-JQ1 Chemical Structure

CAS No. : 1268524-69-1

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规格 价格 是否有货 数量
1 mg ￥1344
1 - 2 周
5 mg ￥3360
1 - 2 周
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

(±)-JQ1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(±)-JQ1 is the racemate of (+)-JQ-1 (HY-13030)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM EC50
2037 nM
Compound: 2; JQ-1
Antiproliferative activity against human CCRF-CEM cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human CCRF-CEM cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
DOHH-2 EC50
279 nM
Compound: 2; JQ-1
Antiproliferative activity against human DOHH2 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human DOHH2 cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
HEK293 CC50
> 20 μM
Compound: JQ1
Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay
Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay
[PMID: 30973727]
HEL 92.1.7 EC50
180 nM
Compound: 2; JQ-1
Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
HepG2 CC50
9.2 μM
Compound: JQ1
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay
[PMID: 30973727]
HL-60 EC50
51 nM
Compound: 2; JQ-1
Antiproliferative activity against human HL60 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human HL60 cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
K562 EC50
> 10000 nM
Compound: 2; JQ-1
Antiproliferative activity against human K562 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human K562 cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
MCF7 IC50
28.75 μM
Compound: 1; JQ1
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 29172540]
MDA-MB-231 IC50
33.04 μM
Compound: 1; JQ1
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
[PMID: 29172540]
MV4-11 EC50
39 nM
Compound: 2; JQ-1
Antiproliferative activity against human MV4-11 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
Raji EC50
330 nM
Compound: 2; JQ-1
Antiproliferative activity against human Raji cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human Raji cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
RPMI-8226 EC50
258 nM
Compound: 2; JQ-1
Antiproliferative activity against human RPMI8226 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human RPMI8226 cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
SUD4 EC50
660 nM
Compound: 2; JQ-1
Antiproliferative activity against human SU-DHL4 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against human SU-DHL4 cells after 72 hrs by Cell-TiterGlo assay
[PMID: 29259751]
分子量

456.99

Formula

C23H25ClN4O2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

(±)-JQ1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-JQ11268524-69-1Epigenetic Reader DomainBET inhibitorsTriazolothienodiazepine (+)-JQ1racemateInhibitorinhibitorinhibit

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产品名称：
(±)-JQ1
目录号：
HY-137075
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