2. Metabolic Enzyme/Protease
  3. 17β-HSD
  4. Rapirosiran

Rapirosiran  (Synonyms: ALN-HSD; ALN-288996; AD-288996)

目录号: HY-164221
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Rapirosiran 是一种与 N-乙酰半乳糖胺结合的小干扰 RNA，它能够靶向肝脏中表达的羟基类固醇 17-β 脱氢酶 13 (HSD17B13) 的 mRNA，可用于非酒精性脂肪性肝炎的研究。HSD17B13 的功能缺失变异体与慢性肝病的风险降低有关。

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RNA, (Am-sp-(2′-deoxy-2′-fluoro)G-sp-Am-Um-Am-Gm-(3′→3′)-[1-de-β-D-ribofuranosyl-1-[(2S)-2,3-dihydroxypropyl]]m5U-(2′→5′)-Cm-Cm-Am-Um-Gm-Cm-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)A-Am-Gm-Cm-Am-Um-sp-Um-sp-Cm), complex with RNA (Am-sp-Um-sp-Gm-Cm-Um-Um-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)A-Um-Gm-Gm-Am-Cm-Um-Am-Um-Cm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1)

Rapirosiran Chemical Structure

CAS No. : 2755196-97-3

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Rapirosiran 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rapirosiran is a N-acetylgalactosamine-conjugated small-interfering RNA targeting liver-expressed hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) mRNA. Loss-of-function variants in the HSD17B13 associated with reduced risk of chronic liver disease. Rapirosiran can be used for the study of Non-alcoholic steatohepatitis.

分子量

16307.22

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Rapirosiran 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rapirosiran2755196-97-3ALN-HSD ALN-288996 AD-288996ALN288996ALN 288996ALN-288996AD288996AD 288996AD-28899617β-HSD17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenaseInhibitorinhibitorinhibit

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