B7-H6 蛋白, Human (HEK293, Fc)

B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Human (HEK293, Fc) is the recombinant human-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H6 Protein, Human (HEK293, Fc) is 262 a.a., with molecular weight of ~53.4 kDa.

B7-H6 是一种独特的蛋白质，可作为 NCR3 依赖性自然杀伤 (NK) 细胞激活的触发因素。作为单体，B7-H6 表现出与 NCR3 的特异性相互作用，明显避免与其他 NK 细胞激活受体（例如 NCR1、NCR2 和 KLRK1）结合。这种相互作用凸显了其在通过 NCR3 途径启动 NK 细胞反应中的独特作用，展示了其在 NK 细胞激活机制的复杂网络中的特异性。

Measured by its binding ability in a functional ELISA. Immobilized human NCR3 at 10μg/mL (100μL/well) can bind B7-H6 Protein, Human (HEK293, Fc) and the EC₅₀ is 20-100ng/mL.

Human

HEK293

C-hFc

Q68D85 (M1-S262)

374383  [NCBI]

MTWRAAASTCAALLILLWALTTEGDLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITSMGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDKYMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFS

Approximately 53.4 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.