1. 重组蛋白
  2. Receptor Proteins
  3. Notch family
  4. Delta-like 4 (DLL4)
  5. Delta-like 蛋白 4/DLL4 蛋白, Mouse (HEK293, Fc)

Delta-like 蛋白 4/DLL4 蛋白, Mouse (HEK293, Fc)

目录号: HY-P75293
产品使用指南

Delta-like 4/DLL4 蛋白是 Notch 信号通路中的关键角色,充当激活 NOTCH1 和 NOTCH4 的配体。在血管生成中,DLL4 调节内皮细胞增殖、迁移和血管生成萌芽。Delta-like 蛋白 4/DLL4 蛋白, Mouse (HEK293, Fc) 是重组的 Delta 样蛋白 4/DLL4 蛋白,由 HEK293 表达,带有 C-mFc 标签。Delta-like 蛋白 4/DLL4 蛋白, Mouse (HEK293, Fc) 全长 525 个氨基酸,分子量约为 ~80.61 kDa。

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描述

Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) is 525 a.a., with molecular weight of ~80.61 kDa.

研究背景

Delta 样蛋白 4/DLL4 蛋白在 Notch 信号通路中发挥着关键作用,作为 Notch 配体并激活 NOTCH1 和 NOTCH4。在血管生成的背景下,DLL4 通过负面影响内皮细胞增殖、迁移和血管生成萌芽而发挥调节作用。该蛋白质对于视网膜祖细胞增殖至关重要,并且是抑制晚期视网膜祖细胞中视杆细胞命运所必需的,同时有助于其他视网膜细胞类型的正确生成。此外,在脊髓神经发生过程中,DLL4 抑制 V2a 中间神经元的命运。它与 NOTCH4 和 NOTCH1 的相互作用突出了其作为 Notch 信号级联中配体的分子基础,强调了其在协调发育过程中关键细胞过程中的多方面功能。

种属

Mouse

表达系统

HEK293

标签

C-mFc

蛋白编号

Q9JI71 (M1-P525)

基因 ID

54485  [NCBI]

蛋白结构
N-term
DLL4 (M1-P525)
Accession # Q9JI71
mFc
C-term
同用名
Delta-like protein 4; Delta4; DLL4
分子量

Approximately 80.61 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc)
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HY-P75293
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