GPVI 蛋白, Human (HEK293, His)

GPVI protein is a collagen receptor that mediates collagen-induced platelet adhesion and activation and plays a crucial role in procoagulant activity, thrombin generation, and fibrin formation. GPVI Protein, Human (HEK293, His) is the recombinant human-derived GPVI protein, expressed by HEK293 , with C-His labeled tag. The total length of GPVI Protein, Human (HEK293, His) is 247 a.a., with molecular weight of 40-60 kDa.

GPVI 蛋白作为胶原受体发挥重要作用，参与介导胶原诱导的血小板粘附和活化。它在血小板促凝血活性中发挥关键作用，导致随后的凝血酶和纤维蛋白形成，从而促进动脉和静脉血栓形成。信号通路涉及 FcR γ 链、Src 激酶（可能是 FYN 或 LYN）、SYK、接头蛋白 LAT，并最终激活 PLCG2。GPVI 与 Fc 受体 γ 链相关，形成 GPVI:FcRgamma 复合物，该复合物进一步与 Src 激酶家族 FYN 和 LYN 连接。此外，GPVI 与 TRAF4 相互作用，并与 COL1A1 特异性结合，突显其参与复杂的信号级联反应及其与胶原蛋白分子的关联，特别是 COL1A1，它是其胶原蛋白结合功能不可或缺的一部分。

Measured by its binding ability in a functional ELISA. When Bovine Collagen I is immobilized, Human GPVI binds with an ED₅₀ of 0.4252 μg/mL, corresponding to a specific activity is 2.35×10^3 units/mg.

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  Measured by its binding ability in a functional ELISA. When Bovine Collagen I is immobilized, Human GPVI binds with an ED₅₀ of 0.4252 μg/mL, corresponding to a specific activity is 2.35×10³ units/mg.

Human

HEK293

C-His

Q9HCN6 (Q21-K267)

51206  [NCBI]

QSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTK

40-60 kDa

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  Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4 or 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.