IL-31R alpha 蛋白, Mouse (HEK293, His)

The IL-31R alpha protein is critical to the immune response and forms the interleukin 31 receptor with OSMR. It activates STAT3, and to a lesser extent STAT1 and STAT5, is associated with skin immunity and mediates IL31-induced itch, possibly involving the cation channels TRPA1 and TRPV1. IL-31R alpha Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-31R alpha protein, expressed by HEK293 , with a C-His labeled tag.

IL-31R α 蛋白在免疫反应中发挥着至关重要的作用，因为它通过与 OSMR 结合形成白细胞介素 31 受体。该受体激活 STAT3，并在较小程度上激活 STAT1 和 STAT5。它被认为参与皮肤免疫并介导 IL31 引起的瘙痒，可能依赖于阳离子通道 TRPA1 和 TRPV1。此外，IL-31R α 在体内和体外均能积极调节骨髓中未成熟髓系祖细胞亚群的数量和循环状态，从而增强髓系祖细胞的存活率。它与 OSMR 形成异二聚体，并与 JAK1 和 STAT3 相互作用。

Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL‑31 RA (HY-P77968) is immobilized at 5 µg/mL (100 µL/well) can bind Biotinylated Mouse IL-31. The ED₅₀ for this effect is 2.916 μg/mL.

Mouse

HEK293

C-His

Q8K5B1-1 (V19-T499)

218624  [NCBI]

Extracellular Domain

80-115 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.