1. 重组蛋白
  2. Enzymes & Regulators Biotinylated Proteins
  3. Hydrolases (EC 3)
  4. PCSK9 蛋白, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi)

PCSK9 蛋白, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi)

目录号: HY-P70546
产品使用指南

PCSK9 蛋白是血浆胆固醇稳态的重要调节因子,影响 LDL 受体家族成员,如 LDLR 和 VLDLR。它促进其细胞内降解并通过非蛋白水解机制增强肝脏 LDLR 降解。PCSK9 蛋白, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi) 是重组的 PCSK9 蛋白,由 HEK293 表达,带有 C-Avi, C-HA, C-8*His 标签。 和 V474I,G670E,, 突变。PCSK9 蛋白, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi) 全长 662 个氨基酸,分子量分别为 18 & 58-70 & 90-150 kDa。

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描述

The PCSK9 protein is an important regulator of plasma cholesterol homeostasis, affecting LDL receptor family members such as LDLR and VLDLR. It promotes their intracellular degradation and enhances hepatic LDLR degradation through non-proteolytic mechanisms. PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi) is the recombinant human-derived PCSK9 protein, expressed by HEK293 , with C-Avi, C-HA, C-8*His labeled tag and V474I, G670E, , , mutation. The total length of PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi) is 662 a.a., with molecular weight of 18 & 58-70 & 90-150 kDa, respectively.

研究背景

PCSK9 蛋白在血浆胆固醇稳态的复杂协调中发挥着关键调节作用。证明其对低密度脂蛋白受体家族成员的影响,包括低密度脂蛋白受体 (LDLR)、极低密度脂蛋白受体 (VLDLR)、载脂蛋白 E 受体 (LRP1/APOER) 和载脂蛋白受体 2 (LRP8/APOER2) ),PCSK9 促进它们在细胞内酸性区室中的降解。它采用非蛋白水解机制,通过网格蛋白 LDLRAP1/ARH 介导的途径增强肝脏 LDLR 降解,可能阻碍 LDLR 回收并将其引导至溶酶体降解。此外,PCSK9 通过自噬体/溶酶体途径表现出 LDLR 独立的 APOB 细胞内降解抑制作用,并在早期分泌途径中非乙酰化 BACE1 中间体的处理中发挥作用。值得注意的是,它通过增强 ENaC 蛋白酶体降解来调节上皮 Na(+) 通道 (ENaC) 介导的 Na(+) 吸收,并通过调节 LRP8/APOER2 水平和相关的抗凋亡信号通路影响神经元凋亡。

种属

Human

表达系统

HEK293

标签

C-Avi;C-HA;C-8*His

蛋白编号

Q8NBP7 (Q31-Q692, V474I, G670E)

基因 ID
蛋白结构
N-term
PCSK9 (Q31-Q692, V474I, G670E)
Accession # Q8NBP7
8*His-HA-Avi
C-term
同用名
Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1
氨基酸序列

QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCRSRHLAQASQELQ

分子量

18&58-70&90-150 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi)
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