1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. PCSK9 蛋白, Rhesus Macaque (HEK293, His)

PCSK9 蛋白, Rhesus Macaque (HEK293, His)

目录号: HY-P75958
COA 产品使用指南

PCSK9 蛋白通过降解 LDLR、VLDLR、LRP1/APOER 和 LRP8/APOER2 受体来调节胆固醇水平。它通过非蛋白水解机制促进 LDLR 降解,破坏 LDLR 循环,诱导 LDLR 泛素化,并抑制 APOB 降解。PCSK9 蛋白, Rhesus Macaque (HEK293, His) 是重组的 PCSK9 蛋白,由 HEK293 表达,带有 C-His 标签。PCSK9 蛋白, Rhesus Macaque (HEK293, His) 全长 662 个氨基酸,分子量分别约为 ~20 & 62 kDa。

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描述

PCSK9 protein regulates cholesterol levels by degrading LDLR, VLDLR, LRP1/APOER and LRP8/APOER2 receptors. It promotes LDLR degradation through non-proteolytic mechanisms, disrupts LDLR recycling, induces LDLR ubiquitination, and inhibits APOB degradation. PCSK9 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PCSK9 protein, expressed by HEK293 , with C-His labeled tag. The total length of PCSK9 Protein, Rhesus Macaque (HEK293, His) is 662 a.a., with molecular weight of ~20 & 62 kDa, respectively.

研究背景

PCSK9蛋白在维持血液中胆固醇水平的平衡中起着至关重要的作用。它与参与脂质代谢的多种受体结合,包括 LDLR、VLDLR、LRP1/APOER 和 LRP8/APOER2,并促进它们在细胞内酸性区室中的降解。它通过网格蛋白 LDLRAP1/ARH 途径介导的非蛋白水解机制增强肝脏 LDLR 的降解。此外,它可能会破坏 LDLR 的回收,将其引导至溶酶体进行降解。PCSK9 还可以诱导 LDLR 泛素化,导致其随后崩溃。此外,它通过自噬体/溶酶体途径抑制 APOB(脂蛋白的重要组成部分)的降解,与 LDLR 无关。在早期分泌途径中,PCSK9 有助于处理 BACE1 的非乙酰化中间体。它还通过增加蛋白酶体降解来减少其表面表达,从而在调节钠离子通过 ENaC 通道的吸收方面发挥作用。最后,PCSK9 通过调节 LRP8/APOER2 的水平和相关的抗凋亡信号通路来调节神经元凋亡。

生物活性

Immobilized Rhesus PCSK9 at 5 µg/mL (100 µL/well) can bind Biotinylated rmLDLR. The ED50 for this effect is 224.2 ng/mL

种属

Rhesus Macaque

表达系统

HEK293

标签

C-His

蛋白编号

A8T666 (Q31-Q692)

基因 ID

717147  [NCBI]

蛋白结构
N-term
PCSK9 (Q31-Q692)
Accession # A8T666
His
C-term
同用名
Proprotein convertase subtilisin/kexin type 9; NARC-1; PC9; PCSK9
氨基酸序列

QEDEDGDYEELVLALRSEEDGLADAPEHGATATFHRCAKDPWRLPGTYVVVLKEETHRSQSERTARRLQAQAARRGYLTKILHVFHHLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPARYRADEYQPPKGGSLVEVYLLDTSIQSDHREIEGRVMVTDFESVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGAGLRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVFNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSRSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHRAGWQLFCRTVWSAHSGPTRMATAVARCAQDEELLSCSSFSRSGKRRGERIEAQGGKRVCRAHNAFGGEGVYAIARCCLLPQVNCSVHTAPPAGASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVIVACEDGWTLTGCSPLPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSKEAVAAVAICCRSRHLVQASQELQ

分子量

Approximately 20&62 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

PCSK9 Protein, Rhesus Macaque (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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